Welcome to SpikePro

Predicting the impact of SARS-CoV-2 spike protein variants on viral fitness

SpikePro predicts the change in the viral fitness of a variant based on its spike protein sequence.

The prediction is based on the impact mutations have on the spike protein's stability, its binding affinity with ACE2 and the binding affinity with neutralizing antibodies. For more details on the methodology, see help.

Predict variant fitness
spike-protein-image Spike protein illustration (made with PyMOL)